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KMID : 0356620080230060420
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Journal of Korean Society of Endocrinology
2008 Volume.23 No. 6 p.420 ~ p.424
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A Case of Methimazole-induced Agranulocytosis and Kikuchi`s Disease in a Patient with Graves` Disease
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Lee Seung-Eun
Ahn Ji-Hyun
Kim Jae-Taek
Oh Yun-Sang
Jung Yoon-Jae
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Abstract
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Methimazole-induced agranulocytosis is a rare, but critical side effect that should be recognized as soon as possible since it may induce a life-threatening condition when it was overlooked. Histiocytic necrotizing lymphadenitis is also called Kikuchi`s lymphadenitis, and this is a rare form of lymphadenitis with a self-limited clinical course and this illness is accompanied by cervical lymph node enlargement, fever and malaise. We recently experienced a patient with methimazole-induced agranulocytosis and Graves` disease, and this was accompanied by Kikuchi`s disease; the patient presented with sore throat and multiple enlarged cervical lymph nodes. To the best of our knowledge, there is no previous report on methimazole-induced agranulocytosis combined with Kikuchi`s disease. Therefore, we report here on this very rare case along with a brief review of the relevant literature.
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KEYWORD
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agranulocytosis, Graves` disease, Kikuchi`s disease
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